EcoR1 Capital Amends AnaptysBio Stake Filing

TL;DR

EcoR1 Capital updated their AnaptysBio filing. Watch this space.

AI Summary

EcoR1 Capital, LLC, a significant shareholder, has filed an amendment to its Schedule 13D regarding AnaptysBio, Inc. The filing, dated August 16, 2024, indicates a change in beneficial ownership. EcoR1 Capital, LLC, based in San Francisco, CA, is a key entity involved in this disclosure.

Why It Matters

This amendment signals a potential shift in the ownership structure or strategy of AnaptysBio, Inc., which could influence its stock performance and corporate direction.

Risk Assessment

Risk Level: medium — Schedule 13D filings often precede significant corporate actions or shifts in control, which can introduce volatility.

Key Players & Entities

• EcoR1 Capital, LLC (company) — Filing entity
• AnaptysBio, Inc. (company) — Subject company
• James J. Frolik, Esq. (person) — Authorized person for notices
• Anthony J. Caldwell, Esq. (person) — Authorized person for notices
• Shartsis Friese LLP (company) — Legal counsel

FAQ

Key Financial Figures

• $0.001 — Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securiti
• $136,419,590 — s Amount the Funds Working Capital $136,419,590 1 1 Includes $130,611,192 paid by Qua
• $130,611,192 — ng Capital $136,419,590 1 1 Includes $130,611,192 paid by Qualified Fund. Item 4. Purpos
• $36.50 — 24 Public Offering by Issuer 273,972 $36.50 Item 6. Contracts, Arrangement, Under

Filing Documents

• anab13da.htm (SC 13D/A) — 49KB
• 0000935836-24-000533.txt ( ) — 51KB

Security and Issuer

Item 1. Security and Issuer This statement relates to shares of Common Stock, $0.001 par value (the “Stock”), of AnaptysBio, Inc. (the “Issuer”). The principal executive office of the Issuer is located at 10770 Wateridge Circle, Suite 210, San Diego, CA 92121 .

Identity and Background

Item 2. Identity and Background The persons filing this statement and the persons enumerated in Instruction C of Schedule 13D and, where applicable, their respective places of organization, general partners, directors, executive officers and controlling persons, and the information regarding them, are as follows: (a) EcoR1 Capital Fund Qualified, L.P. (“Qualified Fund”); EcoR1 Capital, LLC (“EcoR1”) and Oleg Nodelman (“Nodelman”) (collectively, the “Filers”). Qualified Fund is filing this statement jointly with the other Filers, but not as a member of a group and it expressly disclaims membership in a group. In addition, filing this Schedule 13D on behalf of Qualified Fund should not be construed as an admission that it is, and it disclaims that it is, a beneficial owner, as defined in Rule 13d-3 under the Act, of any of the Stock covered by this Schedule 13D. Each Filer also disclaims beneficial ownership of the Stock except to the extent of that person’s pecuniary interest therein. (b) The business address of the Filers is 357 Tehama Street #3, San Francisco, CA 94103 (c) Present principal occupation or employment of the Filers and the name, principal business and address of any corporation or other organization in which such employment is conducted: EcoR1 is an investment adviser to investment funds, including Qualified Fund (collectively, the “Funds”). Mr. Nodelman is the manager and control person of EcoR1. (d) During the last five years, none of the Filers has been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors). (e) During the last five years, none of the Filers was a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or

Source and Amount of Funds or Other Consideration

Item 3. Source and Amount of Funds or Other Consideration The source and amount of funds used in purchasing the Stock were as follows: Purchaser Source of Funds Amount the Funds Working Capital $136,419,590 1 1 Includes $130,611,192 paid by Qualified Fund.

Purpose of Transaction

Item 4. Purpose of Transaction The Filers acquired the Stock for investment purposes based on their belief that the Stock, when purchased, was undervalued and represented an attractive investment opportunity. On April 8, 2021, the Issuer’s Board of Directors appointed Mr. Nodelman to serve as a director of the Issuer. Going forward, the and anticipated future trading prices of the Stock and other securities, the Issuer’s operations, assets, prospects, financial position, and business development, Issuer’s management, Issuer-related competitive and strategic matters, general economic, financial market and industry conditions, and other investment considerations. Depending on their evaluation of various factors, the Filers may take such actions regarding their holdings of the Issuer’s securities as they deem appropriate in light of circumstances existing from time to time. Such actions may include purchasing additional Stock in the open market, through privately negotiated transactions with third parties or otherwise, and selling at any time, in the open market, through privately negotiated transactions with third parties or otherwise, all or part of the Stock that they now own or hereafter acquire. The Filers also may from time to time enter into or unwind hedging or other derivative transactions with respect to the Stock or pledge their interests in the Stock to obtain liquidity. In addition, from time to time the Filers and their representatives and advisers may communicate with other stockholders, industry participants and other interested parties about the Issuer. The Filers have no present plan or proposal that relates to or would result in any of the actions specified in clauses (a) through (j) of Item 4 of Schedule 13D. However, the Filers may recommend action to the Issuer’s management,

Interest in Securities of the Issuer

Item 5. Interest in Securities of the Issuer The beneficial ownership of the Stock by each Filer on the date hereof is reflected on that Filer’s cover page. The Filers engaged in the following transactions in the Issuer’s Stock in the 60 days preceding the date of this Schedule 13D: Name Purchase or Sale Date Manner Effected Number of Shares Price Per Share Qualified Fund Purchase 8/14/2024 Public Offering by Issuer 273,972 $36.50

Contracts, Arrangement, Understandings or Relationships with Respect to Securities of the Issuer

Item 6. Contracts, Arrangement, Understandings or Relationships with Respect to Securities of the Issuer EcoR1 is the investment adviser to its clients pursuant to investment management agreements or limited partnership agreements providing to EcoR1 the authority, among other things, to invest the funds of such clients in Stock, to vote and dispose of Stock and to file this statement on behalf of such clients. Pursuant to such limited partnership agreements, EcoR1 is entitled to allocations based on assets under management and realized and unrealized gains. Pursuant to such investment management agreements, EcoR1 is entitled to fees based on assets under management and realized and unrealized gains.

Material to Be Filed as Exhibits

Item 7. Material to Be Filed as Exhibits Exhibit AAgreement Regarding Joint Filing of Statement on Schedule 13D or 13G.

SIGNATURES

SIGNATURES After reasonable inquiry and to the best of my knowledge, I certify that the information set forth in this statement is true, complete and correct. Dated:August 15, 2024 EcoR1 CAPITAL, LLC By: /s/ Oleg Nodelman Oleg Nodelman Manager EcoR1 CAPITAL FUND QUALIFIED, L.P. By:EcoR1 Capital, LLC, General Partner By: /s/ Oleg Nodelman Oleg Nodelman Manager /s/ Oleg Nodelman Oleg Nodelman 5 CUSIP No. 032724106 EXHIBIT A AGREEMENT REGARDING JOINT FILING OF STATEMENT ON SCHEDULE 13D OR 13G The undersigned agree to file jointly with the Securities and Exchange Commission (the “SEC”) any and all statements on Schedule 13D, Schedule 13G or forms 3, 4 or 5 (and any amendments or supplements thereto) required under section 13(d) or 16(a) of the Securities Exchange Act of 1934, as amended, in connection with purchases by the undersigned of the securities of any issuer. For that purpose, the undersigned hereby constitute and appoint EcoR1 Capital, LLC, a Delaware limited liability company, as their true and lawful agent and attorney-in-fact, with full power and authority for and on behalf of the undersigned to prepare or cause to be prepared, sign, file with the SEC and furnish to any other person all certificates, instruments, agreements and documents necessary to comply with section 13(d) and section 16(a) of the Act, in connection with said purchases, and to do and perform every act necessary and proper to be done incident to the exercise of the foregoing power, as fully as the undersigned might or could do if personally present. Dated:August 15, 2024 EcoR1 CAPITAL, LLC By: /s/ Oleg Nodelman Oleg Nodelman Manager EcoR1 CAPITAL FUND QUALIFIED, L.P. By:EcoR1 Capital, LLC, General Partner By: /s/ Oleg Nodelman Oleg Nodelman Manager /s/ Oleg Nodelman Oleg Nodelman

View Full Filing

View this SC 13D/A filing on SEC EDGAR