Metagenomi Enters and Terminates Material Agreements

TL;DR

Metagenomi just signed AND axed a big deal. What gives?

AI Summary

On September 29, 2025, Metagenomi, Inc. entered into a material definitive agreement and also terminated a material definitive agreement. The company, formerly known as Metagenomi Technologies, LLC, is headquartered in Emeryville, California.

Why It Matters

The simultaneous entry into and termination of material definitive agreements suggests significant strategic shifts or renegotiations that could impact the company's operations and future partnerships.

Risk Assessment

Risk Level: medium — The simultaneous entry into and termination of material definitive agreements indicates potential instability or significant changes in business strategy, which carries inherent risk.

Key Players & Entities

• Metagenomi, Inc. (company) — Registrant
• Metagenomi Technologies, LLC (company) — Former Name
• September 29, 2025 (date) — Date of earliest event reported
• Emeryville, California (location) — Principal Executive Offices

FAQ

Key Financial Figures

• $0.0001 — nge on which registered Common Stock, $0.0001 par value per share MGX Nasdaq Glob

Filing Documents

• mgx-20250929.htm (8-K) — 45KB
• 0001193125-25-226878.txt ( ) — 153KB
• mgx-20250929.xsd (EX-101.SCH) — 25KB
• mgx-20250929_htm.xml (XML) — 5KB

01 Entry into a Material Definitive Agreement

Item 1.01 Entry into a Material Definitive Agreement. On September 29, 2025 (the "Effective Date"), Metagenomi, Inc. (the "Company") entered into a Non-Exclusive License Agreement (the "Acuitas License Agreement") with Acuitas Therapeutics, Inc. ("Acuitas") pursuant to which Acuitas granted the Company a non-exclusive license to certain Acuitas lipid nanoparticle ("LNP") technology, including LNP patents, formulation processes, and analytical characterization methods for manufacturing products that incorporate the Company's proprietary genome editing constructs formulated with Acuitas LNP technology, to research, develop, sell, and commercialize certain licensed products in connection with a single target as further set forth in the Acuitas License Agreement. Under the Acuitas License Agreement, the Company will pay to Acuitas (i) a license maintenance fee in the low seven figures, payable on the one year anniversary of the Effective Date and each twelve month anniversary thereafter until such time as the first patient is dosed in a Phase 1 study for a licensed product under the Acuitas License Agreement; (ii) milestone payments in the low to mid seven figures upon certain regulatory and commercialization milestones; and (iii) royalties in the low mid-single digit percentage of net sales. The Acuitas License Agreement will remain in effect on a licensed product-by-licensed product and country-by-country basis until there are no outstanding royalty payments owed to Acuitas. Further, the Acuitas License Agreement may be terminated by either party for material breach or upon a party's insolvency or bankruptcy, and Acuitas may immediately terminate in specified situations. Upon 30 days written notice, the Company has the right to terminate the Acuitas License Agreement at its discretion. The Acuitas License Agreement also includes customary representations and warranties, covenants and indemnification obligations. The foregoing summary of the terms of the Acui

02 Termination of a Material Definitive Agreement

Item 1.02 Termination of a Material Definitive Agreement. On September 30, 2025 (the "Termination Date"), the Company delivered to Affini-T Therapeutics, Inc. ("Affini-T") a notice to terminate the Development, Option and License Agreement dated June 14, 2022 (the "Affini-T License Agreement") by and between the Company and Affini-T (the "Termination"), effective immediately, due to Affini-T's making of an assignment for the benefit of creditors, as permitted pursuant to Section 12.2.3 of the Affini-T License Agreement. Under the Affini-T License Agreement, the Company and Affini-T agreed to identify, develop, or optimize certain reagents using the Company's proprietary technology for Affini-T to use such reagents to develop and commercialize gene edited T-cell receptor ("TCR")-based therapeutic products exclusively in the field of treatment, prevention or diagnosis of any human cancer using products with any engineered primary TCR alpha/beta T cells and non-exclusively in the field of treatment, prevention or diagnosis of any human cancer using products with certain other engineered immune cells worldwide. As a result of the Termination, the Company regained (i) full control over all intellectual property rights it had licensed to Affini-T for developing TCR-based therapeutic products that were subject to the Affini-T License Agreement; (ii) the right to freely operate in areas where it was previously restricted pursuant to the Affini-T License Agreement; and (iii) full control over the manufacture and supply of its proprietary reagents. Effective as of the Termination Date, the Affini-T License Agreement was terminated in its entirety and the rights and licenses granted thereunder terminated in all respects. Following the Termination Date, the Company will not be entitled to receive any future payments from Affini-T pursuant to the Affini-T License Agreement. The foregoing summary of the Affini-T License Agreement is qualified in its entirety by reference

SIGNATURES

SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. Metagenomi, Inc. Date: October 1, 2025 By: /s/ Brian C. Thomas Brian C. Thomas, Ph.D. Chief Executive Officer

View Full Filing

View this 8-K filing on SEC EDGAR