Adage Capital Partners Amends Protagonist Therapeutics Stake

TL;DR

**Adage Capital Partners just updated their Protagonist Therapeutics stake, watch for market reaction.**

AI Summary

Adage Capital Partners, L.P. filed an amended SC 13G/A on February 7, 2024, indicating a change in their ownership of Protagonist Therapeutics, Inc. common stock as of December 31, 2023. This filing updates their previous disclosure, signaling a potential shift in their investment strategy or a rebalancing of their portfolio. For investors, this matters because large institutional ownership changes can influence stock price and signal confidence (or lack thereof) in the company's future prospects.

Why It Matters

This filing shows an institutional investor, Adage Capital Partners, updated their position in Protagonist Therapeutics, which can signal their evolving view on the company's value.

Risk Assessment

Risk Level: medium — Changes in institutional ownership can introduce volatility, as other investors may react to the perceived sentiment of large funds.

Analyst Insight

Investors should monitor subsequent filings from Adage Capital Partners to understand the full scope of their investment changes and consider how this might align with their own investment thesis for Protagonist Therapeutics.

Key Players & Entities

• Adage Capital Partners, L.P. (company) — the reporting person filing the SC 13G/A
• Protagonist Therapeutics, Inc. (company) — the issuer of the securities being reported
• December 31, 2023 (date) — the date of the event requiring the filing
• February 7, 2024 (date) — the filing date of the SC 13G/A
• 74366E102 (other) — CUSIP number for Protagonist Therapeutics common stock

FAQ

Key Financial Figures

• $0.00001 — me of Issuer) Common Stock, par value $0.00001 per share (Title of Class of Securitie

Filing Documents

• p24-0421sc13ga.htm (SC 13G/A) — 99KB
• 0000902664-24-001166.txt ( ) — 101KB

(a)

Item 1(a). NAME OF ISSUER The name of the issuer is Protagonist Therapeutics, Inc. (the “ Company ”).

(b)

Item 1(b). ADDRESS OF ISSUER’S PRINCIPAL EXECUTIVE OFFICES The Company’s principal executive offices are located at 7707 Gateway Boulevard, Suite 140, Newark, California 94560.

(a)

Item 2(a). NAME OF PERSON FILING This statement is filed by: (i) Adage Capital Partners, L.P., a Delaware limited partnership (“ ACP ”) with respect to the Common Stock directly owned by it; (ii) Adage Capital Partners GP, L.L.C., a limited liability company organized under the laws of the State of Delaware (“ ACPGP ”), as general partner of ACP with respect to the Common Stock directly owned by ACP; (iii) Adage Capital Advisors, L.L.C., a limited liability company organized under the laws of the State of Delaware (“ ACA ”), as managing member of ACPGP, general partner of ACP, with respect to the Common Stock directly owned by ACP; (iv) Robert Atchinson (“ Mr. Atchinson ”), as managing member of ACA, managing member of ACPGP, general partner of ACP with respect to the Common Stock directly owned by ACP; and (v) Phillip Gross (“ Mr. Gross ”), as managing member of ACA, managing member of ACPGP, general partner of ACP with respect to the Common Stock directly owned by ACP. The foregoing persons are hereinafter sometimes collectively referred to as the “ Reporting Persons .” Any disclosures herein with respect to persons other than the Reporting Persons are made on information and belief after making inquiry to the appropriate party. The filing of this statement should not be construed in and of itself as an admission by any Reporting Person as to beneficial ownership of the securities reported herein.

(b)

Item 2(b). ADDRESS OF PRINCIPAL BUSINESS OFFICE OR, IF NONE, RESIDENCE The address of the business office of each of the Reporting Persons is 200 Clarendon Street, 52nd Floor, Boston, Massachusetts 02116. CUSIP No. 74366E102 13G/A Page 8 of 11 Pages

(c)

Item 2(c). CITIZENSHIP ACP is a limited partnership organized under the laws of the State of Delaware. ACPGP and ACA are limited liability companies organized under the laws of the State of Delaware. Messrs. Gross and Atchinson are citizens of the United States.

(d)

Item 2(d). TITLE OF CLASS OF SECURITIES Common stock, par value $0.00001 per share (the “ Common Stock ”).

(e)

Item 2(e). CUSIP NUMBER 74366E102 Item 3. IF THIS STATEMENT IS FILED PURSUANT TO Rules 13d-1(b), OR 13d-2(b) OR (c), CHECK WHETHER THE PERSON FILING IS A: (a) Broker or dealer registered under Section 15 of the Act; (b) Bank as defined in Section 3(a)(6) of the Act; (c) Insurance company as defined in Section 3(a)(19) of the Act; (d) Investment company registered under Section 8 of the Investment Company Act of 1940; (e) An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E); (f) An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F); (g) A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G); (h) A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act; (i) A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company Act; (j) A non-U.S. institution in accordance with Rule 13d-1(b)(1)(ii)(J); (k) Group, in accordance with Rule 13d-1(b)(1)(ii)(K). If filing as a non-U.S. institution in accordance with Rule 13d-1(b)(1)(ii)(J), please specify the type of institution : Not applicable. Item 4. A. Adage Capital Partners, L.P., Adage Capital Partners GP, L.L.C. and Adage Capital Advisors, L.L.C. (a) Amount beneficially owned: 1,291,701 CUSIP No. 74366E102 13G/A Page 9 of 11 Pages (b) Percent of class: 2.24%. The percentage set forth in this Schedule 13G/A is calculated based upon the 57,678,122 shares of Common Stock outstanding as of October 27, 2023, as reported in the Company’s Quarterly Report on Form 10-Q for the quarterly period ended September 30, 2023, filed with the Securities and Exchange Commission on November 2, 2023. (c) (i) Sole power to vote or direct the vote: 0 (ii) Shared power to vote or direct the vote: 1,291,701 (iii) Sole power to dispose or direct the disposition: 0 (iv) Shared power to dispose or

SIGNATURES

SIGNATURES After reasonable inquiry and to the best of his or its knowledge and belief, each of the undersigned certifies that the information set forth in this statement is true, complete and correct. DATE: February 7, 2024 ADAGE CAPITAL PARTNERS, L.P. By: Adage Capital Partners GP, L.L.C., its general partner By: Adage Capital Advisors, L.L.C., its managing member /s/ Robert Atchinson Name: Robert Atchinson Title: Managing Member ADAGE CAPITAL PARTNERS GP, L.L.C. By: Adage Capital Advisors, L.L.C., its managing member /s/ Robert Atchinson Name: Robert Atchinson Title: Managing Member ADAGE CAPITAL ADVISORS, L.L.C. /s/ Robert Atchinson Name: Robert Atchinson Title: Managing Member ROBERT ATCHINSON /s/ Robert Atchinson ROBERT ATCHINSON, individually PHILLIP GROSS /s/ Phillip Gross PHILLIP GROSS, individually

View Full Filing

View this SC 13G/A filing on SEC EDGAR